Publications

[15] S Mehta*, A Buyanbat*, Yan Kai*, O Karayel, SR Goldman, D Seruggia, et al. (2022). Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chemical Biology.

[14] N Liu, S Xu, Q Yao, Q Zhu, Yan Kai, JY Hsu, P Sakon, L Pinello, GC Yuan, et al. (2021). Transcription factor competition at the γ-globin promoters controls hemoglobin switching. Nature Genetics 53 (4), 511-520.

[13] Yan Kai, BE Li, M Zhu, GY Li, F Chen, Y Han, HJ Cha, SH Orkin, W Cai, et al. (2021). Mapping the evolving landscape of super-enhancers during cell differentiation. Genome Biology 22, 1-21.

[12] HJ Cha, Ö Uyan*, Y Kai*, T Liu, Q Zhu, Z Tothova, GA Botten, J Xu, et al. (2021). Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Nature Communications 12 (1), 1-19.

[11] S Perkail, J Andricovich, Y Kai, A Tzatsos (2020). BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nature Communications 11 (1), 3018.

[10] Y Zhang*, X Wu*, Y Kai*, CH Lee, F Cheng, Y Li, Y Zhuang, et al. (2019). Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. JCI Insight 4 (24).

[9] J Sun, X Cai, MMH Yung, W Zhou, J Li, Y Zhang, Z Li, SS Liu, et al. (2019). miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer. Oncogene 38 (4), 564.

[5] Yan Kai, J Andricovich, Z Zeng, J Zhu, A Tzatsos, W Peng (2018). Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features. Nature Communications 9 (1), 4221.

[8] J Andricovich, S Perkail, Yan Kai, N Casasanta, W Peng, A Tzatsos (2018). Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors. Cancer Cell 33 (3), 512-526.e8.

[7] W Zhou, W Sun, MMH Yung, S Dai, Y Cai, CW Chen, Y Meng, JB Lee, et al. (2018). Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance. Oncogene, 1.