Paper-Conference

[25] DISSECTING THE MOLECULAR BASIS OF POTENT HBF INDUCTION BY BMS-986470: A MECHANISTIC STUDY OF ZBTB7A/WIZ DUAL DEGRADATION featured image

Molecular Basis of HbF Induction by BMS-986470: ZBTB7A/WIZ Dual Degradation

We delineated the transcriptional and chromatin-level mechanisms of HbF regulation by BMS-986470, a first-in-class CELMoD that dually degrades ZBTB7A and WIZ, and established a …

y-kai
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[24] Development of a novel Ikaros/Aiolos transcriptional signature and correlation with patient response in multiple myeloma patients treated with CELMoDs featured image

An RNA-seq Biomarker for CELMoD Response in Multiple Myeloma

We developed a quantitative RNA-seq based Ikaros/Aiolos activity score that is significantly associated with patient progression-free survival in multiple myeloma patients treated …

s-tamim
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