Article-Journal

[13] Mapping the evolving landscape of super-enhancers during cell differentiation featured image

Charting the Evolving Landscape of Super-Enhancers

We mapped the dynamic landscape of super-enhancers during erythroid differentiation, revealing how these large regulatory elements evolve to drive cell identity.

Yan Kai

• Jan 2, 2021 • 1 min read

[12] Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture

hj-cha

• Jan 1, 2021 • 1 min read

[11] BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice

s-perkail

• Jan 1, 2020 • 1 min read

[10] Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer

y-zhang

• Dec 1, 2019 • 1 min read

[9] miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer

j-sun

• Jan 1, 2019 • 1 min read

[5] Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features featured image

Predicting the 3D Genome with Machine Learning

We developed a machine learning framework to predict 3D chromatin loops mediated by CTCF, integrating genomic motif orientation with epigenomic features.

Yan Kai

• Sep 1, 2018 • 1 min read

[8] Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors featured image

How Losing an Epigenetic Eraser Drives Pancreatic Cancer

We found that loss of the histone demethylase KDM6A activates a specific super-enhancer program, driving a distinct, aggressive subtype of pancreatic cancer.

j-andricovich

• Mar 1, 2018 • 1 min read