Article-Journal

[23] Golcadomide: An Oral CELMoD Agent Targeting IKZF1/3 For Diffuse Large B-Cell Lymphoma

Sugar Coating Drives Drug Resistance in Breast Cancer

We identified O-GlcNAcylation as a critical regulator of MITF activity, driving resistance to CDK4/6 inhibitors in breast cancer.

[21] Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions

[20] Mechanistic and kinetic insights into Transcription factor biology via acute protein depletion

Detecting Compartment Switches in the 3D Genome

We developed DARIC (Differential Analysis of Regulated In-Compartments) to systematically identify significant chromosomal compartmentalization changes from Hi-C data.

Yan Kai

• Jan 1, 2023 • 1 min read

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[18] MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

[16] A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

[17] Lysine methyltransferase Kmt2d regulates naive CD8+ T cell activation-induced survival

Real-Time Kinetics of Gene Derepression via PROTAC

Using PROTAC technology, we resolved the precise kinetics of hemoglobin switching, revealing that transcription activation precedes chromatin remodeling.

The Molecular Tug-of-War Behind Hemoglobin Switching

We uncovered a direct competition mechanism between BCL11A and other activators at the gamma-globin promoter, determining the developmental switch.