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All Publications
* indicates equal contributions
[25]
Y Kai
,
et al.
(2026).
DISSECTING THE MOLECULAR BASIS OF POTENT HBF INDUCTION BY BMS-986470: A MECHANISTIC STUDY OF ZBTB7A/WIZ DUAL DEGRADATION
.
EHA Library
. European Hematology Association Annual Congress 2026; Stockholm, Sweden.
Source Document
[24]
S Tamim
,
N Stong
,
Y Kai
,
D Jankeel
,
B Gaffney
,
A Kurtova
,
AR Perez
,
C Fontanillo
,
TT Chow
,
PR Hagner
,
D Jeyaraju
,
CC Bjorklund
,
M Amatangelo
,
K Wang
,
A Gandhi
,
M Ortiz-Estevez
(2026).
Development of a novel Ikaros/Aiolos transcriptional signature and correlation with patient response in multiple myeloma patients treated with CELMoDs
.
Cancer Research
86 (7 Suppl), Abstract nr 2714. AACR Annual Meeting 2026; San Diego, CA.
[23]
Z Mo
,
L Groocock
,
S Wood
,
D Jankeel
,
D Mendy
,
ER Watson
,
Y Kai
,
et al.
(2025).
Golcadomide: An Oral CELMoD Agent Targeting IKZF1/3 For Diffuse Large B-Cell Lymphoma
.
Blood Cancer Discovery
.
PDF
[22]
Y Zhang*
,
S Zhou*
,
Yan Kai*
,
Y Zhang
,
C Peng
,
Z Li
,
MJ Mughal
,
B Julie
,
et al.
(2024).
O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer
.
Nature Communications
15 (1), 5597.
PDF
[21]
T Liu
,
Q Zhu
,
Y Kai
,
T Bingham
,
S Wang
,
HJ Cha
,
S Mehta
,
TM Schlaeger
,
et al.
(2024).
Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions
.
Nature Communications
15 (1), 1274.
Dataset
PDF
[20]
S Mehta
,
A Buyanbat
,
Y Kai
,
SH Orkin
(2024).
Mechanistic and kinetic insights into Transcription factor biology via acute protein depletion
.
Experimental Hematology
, 104250.
PDF
[19]
Yan Kai
,
N Liu
,
SH Orkin
,
GC Yuan
(2023).
Identifying Quantitatively Differential Chromosomal Compartmentalization Changes and Their Biological Significance from Hi-C data using DARIC
.
BMC Genomics
.
Code
Dataset
PDF
[18]
SN Olsen
,
L Godfrey
,
JP Healy
,
YA Choi
,
Y Kai
,
C Hatton
,
F Perner
,
et al.
(2022).
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
.
Molecular Cell
82 (6), 1140-1155.e11.
PDF
[17]
N Weng
,
J Kim
,
T Nguyen
,
J Cifello
,
R Ahmad
,
Y Zhang
,
Q Yang
,
JE Lee
,
et al.
(2022).
Lysine methyltransferase Kmt2d regulates naive CD8+ T cell activation-induced survival
.
Frontiers in Immunology
13, 8240.
Dataset
PDF
[16]
T Harada
,
Y Heshmati
,
J Kalfon
,
MW Perez
,
JX Ferrucio
,
J Ewers
,
et al.
(2022).
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia
.
Genes & Development
36 (5-6), 368-389.
PDF
[15]
S Mehta*
,
A Buyanbat*
,
Yan Kai*
,
O Karayel
,
SR Goldman
,
D Seruggia
,
et al.
(2022).
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
.
Cell Chemical Biology
.
Dataset
PDF
[14]
N Liu
,
S Xu
,
Q Yao
,
Q Zhu
,
Yan Kai
,
JY Hsu
,
P Sakon
,
L Pinello
,
GC Yuan
,
et al.
(2021).
Transcription factor competition at the γ-globin promoters controls hemoglobin switching
.
Nature Genetics
53 (4), 511-520.
Dataset
PDF
[13]
Yan Kai
,
BE Li
,
M Zhu
,
GY Li
,
F Chen
,
Y Han
,
HJ Cha
,
SH Orkin
,
W Cai
,
et al.
(2021).
Mapping the evolving landscape of super-enhancers during cell differentiation
.
Genome Biology
22, 1-21.
Dataset
PDF
[12]
HJ Cha
,
Ö Uyan*
,
Y Kai*
,
T Liu
,
Q Zhu
,
Z Tothova
,
GA Botten
,
J Xu
,
et al.
(2021).
Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture
.
Nature Communications
12 (1), 1-19.
Dataset
PDF
[11]
S Perkail
,
J Andricovich
,
Y Kai
,
A Tzatsos
(2020).
BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
.
Nature Communications
11 (1), 3018.
Dataset
PDF
[10]
Y Zhang*
,
X Wu*
,
Y Kai*
,
CH Lee
,
F Cheng
,
Y Li
,
Y Zhuang
,
et al.
(2019).
Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer
.
JCI Insight
4 (24).
PDF
[9]
J Sun
,
X Cai
,
MMH Yung
,
W Zhou
,
J Li
,
Y Zhang
,
Z Li
,
SS Liu
,
et al.
(2019).
miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer
.
Oncogene
38 (4), 564.
PDF
[8]
J Andricovich
,
S Perkail
,
Yan Kai
,
N Casasanta
,
W Peng
,
A Tzatsos
(2018).
Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors
.
Cancer Cell
33 (3), 512-526.e8.
Dataset
PDF
[7]
W Zhou
,
W Sun
,
MMH Yung
,
S Dai
,
Y Cai
,
CW Chen
,
Y Meng
,
JB Lee
,
et al.
(2018).
Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance
.
Oncogene
, 1.
Dataset
PDF
[6]
Y Meng
,
CW Chen
,
MMH Yung
,
W Sun
,
J Sun
,
Z Li
,
J Li
,
Z Li
,
W Zhou
,
et al.
(2018).
DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer
.
Cancer Letters
.
Dataset
PDF
[5]
Yan Kai
,
J Andricovich
,
Z Zeng
,
J Zhu
,
A Tzatsos
,
W Peng
(2018).
Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
.
Nature Communications
9 (1), 4221.
Code
PDF
[4]
L Phan
,
J Hsu
,
M Willi
,
T Mansour
,
Y Kai
,
J Garner
,
J Lopez
,
B Busby
(2017).
dbVar structural variant cluster set for data analysis and variant comparison
.
F1000Research
5.
PDF
[3]
J Andricovich
,
Y Kai
,
A Tzatsos
(2016).
Lysine-specific histone demethylases in normal and malignant hematopoiesis
.
Experimental Hematology
44 (9), 778-782.
PDF
[2]
J Andricovich
,
Y Kai
,
W Peng
,
A Foudi
,
A Tzatsos
(2016).
Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis
.
Journal of Clinical Investigation
.
Dataset
PDF
[1]
J Yin
,
R Chang
,
Y Kai
,
X Zhao
(2013).
Highly stable and AC electric field-activated electrorheological fluid based on mesoporous silica-coated graphene nanosheets
.
Soft Matter
9 (15), 3910-3914.